A scientific review published in the Journal of Holistic Integrative Pharmacy suggests that Polygonum multiflorum, a root used in traditional Chinese medicine, may offer multiple mechanisms for treating androgenetic alopecia (AGA).
Key Findings
The herb may reduce the impact of dihydrotestosterone (DHT) on hair follicles.
It may inhibit premature follicle cell death.
It may activate Wnt and Shh signaling pathways involved in hair growth.
It may improve scalp blood circulation.
Evidence Sources
The review draws on laboratory research, clinical reports, and historical herbal records. The authors emphasize that traditional claims are compared to modern biological findings to identify overlaps.
Safety Considerations
The authors note that proper traditional processing is essential for safety. Processed Polygonum multiflorum may present fewer side effects than current medications like finasteride and minoxidil.
Limitations
The review highlights the need for larger, controlled human trials to confirm efficacy and safety across diverse populations.