Key Finding: A study found that gut microbiome and metabolite alterations remain detectable more than 10 years after removal of colorectal adenomas.
Study Details:
- Published in Cell Host & Microbe on May 27.
- Used health data and stool samples from women in the Nurses' Health Study II.
- Compared gut microbiomes of 354 participants who had an adenoma removed (average 12 years post-removal) with 354 matched adenoma-free participants.
- Previous studies had only examined microbiomes around the time of removal.
Interpretation:
- The researchers stated that the findings suggest the gut microbiome may be a biological contributor to sustained CRC risk after adenoma removal.
- They noted that the study shows association, not causation, and that further research is needed to test whether modifying the microbiome through diet and exercise alters CRC risk.
Key Findings
- These changes may contribute to sustained elevated risk of colorectal cancer (CRC) in individuals with a history of adenoma.
- Diet and physical activity were more strongly associated with abundance of CRC-associated gut microbes in individuals with a history of adenoma than in those without.
A study led by Harvard T.H. Chan School of Public Health found that gut microbiome and metabolite alterations remain detectable more than 10 years after removal of colorectal adenomas.