Christina Applegate Hospitalized in Los Angeles

"I have no comment on whether she is in the hospital or what her medical treatments are. She's had a long history of complicated medical conditions that she has been refreshingly open about..."

Actress Christina Applegate was hospitalized in Los Angeles in late March 2024, according to multiple reports. The specific reason for her hospitalization has not been publicly confirmed by her representatives, who have declined to comment on her condition or medical treatments. Applegate has a publicly known history of multiple sclerosis and other medical conditions.

Reported Hospitalization

Multiple sources, including TMZ, reported that Christina Applegate was hospitalized in Los Angeles in late March 2024. The circumstances and specific reason for the hospitalization have not been disclosed. It is unknown whether the hospitalization is related to her multiple sclerosis diagnosis.

Official Response

A representative for Applegate addressed the reports with a statement but did not confirm or deny the hospitalization. The representative told TMZ, "I have no comment on whether she is in the hospital or what her medical treatments are. She's had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast."

Representatives did not respond to a separate request for comment from Parade.

Background on Applegate's Health

Christina Applegate, 54, publicly disclosed a diagnosis of multiple sclerosis (MS) in 2021. MS is a condition that affects communication between the brain and body and can cause symptoms including difficulty with coordination, vision changes, and fatigue.

In her 2024 memoir, "You With the Sad Eyes," she described daily challenges, writing, "When I wake up, I often can't get my arm to move far enough to grab the cup of water by my bed or my phone from its charger."

On her podcast and in interviews, Applegate has discussed the impact of MS on her life. She stated in early 2025 that MS symptoms had resulted in approximately 30 hospital visits over the previous three years, including for a double kidney infection in the summer of 2025.

In a March 2026 appearance on NPR's "Wild Card With Rachel Martin," Applegate said she thinks about death "every day 'cause it's looming" and has made arrangements including purchasing burial plots. In 2024, she stated on her podcast that she does not "enjoy living" and experiences depression.

Applegate is known for her acting roles, including in the series "Dead to Me." Her memoir has received positive feedback from colleagues, including former co-star Chevy Chase.