Researchers analyzed blood and skin samples from patients with guttate psoriasis. This analysis utilized single-cell technologies, enabling a detailed examination of hundreds of thousands of individual immune cells.
The study indicated that neutrophils, a common type of immune cell, behave differently based on their environmental context during a streptococcal infection.
A notable discovery was a group of neutrophils capable of presenting antigens. These antigen-presenting neutrophils were observed to accumulate in the affected skin of individuals with guttate psoriasis and were able to activate T cells, a process that may contribute to inflammation.
These antigen-presenting neutrophils were observed to accumulate in the affected skin of individuals with guttate psoriasis and were able to activate T cells, a process that may contribute to inflammation.