Russian scientists, primarily from ITMO University, have developed a new photothermal cancer immunotherapy. This method utilizes light-sensitive microcarriers to release an immunomodulating drug precisely within cancerous tumors upon exposure to a laser, aiming to control immune responses, minimize side effects, and prevent harm to healthy tissues.
The precise control offered by this method is intended to minimize potential side effects and prevent unintended impact on healthy tissues surrounding the tumor.
Introduction to the Technology
Scientists in Russia have developed a new photothermal cancer immunotherapy. This development, announced by ITMO University, is designed to offer precise control over immune responses within cancerous tumors.
Mechanism of Action
The therapeutic method employs light-sensitive microcarriers. These microcarriers are engineered to release an immunomodulating drug when exposed to a laser. Lidia Mikhailova, a junior researcher at ITMO's Faculty of Physics, stated that the drug's release and activation can be controlled remotely. The drug is intended to remain inactive after injection until a laser is directed at the specific tumor location. This mechanism is intended to allow for drug administration "at the right time and in the right amount," according to ITMO University.
Stated Benefits and Goals
The precise control offered by this method is intended to minimize potential side effects and prevent unintended impact on healthy tissues surrounding the tumor.
Context on Tumor Behavior
Researchers also provided context on tumor behavior. They noted that tumor development and survival are influenced by both genetic changes in cancer cells and their interactions with surrounding tissues. Many tumors have been observed to alter or reprogram immune cells, specifically macrophages, which can subsequently protect the tumor instead of targeting it.